Spyre Therapeutics Inc. (SYRE)
SYRE trades on Nasdaq in Health Care, Biotechnology: Pharmaceutical Preparations. Numbers below come from the Nasdaq screener and SEC filings, each with its source.
Price · October 14, 2026
$80.45
-6.34% on the day
Market cap
$7.1B
Mid cap
Revenue · 2025
$0
Prior year not contiguous
Net income · 2025
-$155.2M
Price, change, market cap, sector and industry: Nasdaq stock screener, as of October 14, 2026. Revenue: SEC XBRL frames, calendar 2025.
Profile
| Field | Value |
|---|---|
| Ticker | SYRE on Nasdaq |
| Sector | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations |
| Country | United States |
| IPO year | 2016 |
| SEC CIK | 0001636282 |
| SEC industry code | Pharmaceutical Preparations |
| Incorporated in | DE |
Financials · 2025
| Line | Value |
|---|---|
| Revenue | $0 |
| Net income | -$155.2M |
| Operating income | -$209.6M |
| Net margin | Needs revenue and net income |
| Operating margin | Operating income not reported |
| Revenue growth | No prior-year revenue to compare |
| Cash | $85.7M |
| Total assets | $777.8M |
| P/E (computed) | Net income was not positive |
| P/S (computed) | Needs market cap and revenue |
Key SEC documents
| Document | Form | Filed |
|---|---|---|
| Latest prospectus or offering document | 424B5 | 2026-10-06 |
| Latest annual report | 10-K | 2026-02-19 |
| Latest quarterly / interim | 10-Q | 2026-08-04 |
| Latest current report | 8-K | 2026-10-07 |
| Latest proxy | DEFA14A | 2026-04-10 |
Source: SEC EDGAR submissions feed, 821 recent filings. All filings on EDGAR.
Price moves
| Window | Return |
|---|---|
| 1 week | -2.2% |
| 1 month | -13.0% |
| 3 months | -16.0% |
| Year to date | +141.5% |
| 1 year | +318.2% |
| From 52-week high | -27.4% |
Source: Yahoo Finance daily closes, last bar 2026-10-14. Computed by Sophia Capital from daily closes; cap, sector and tier from the Nasdaq screener.
Peers in Biotechnology: Pharmaceutical Preparations
| Ticker | Company | Price | Day | Market cap |
|---|---|---|---|---|
| IONS | Ionis Pharmaceuticals Inc. | $42.38 | -2.95% | $7.0B |
| AMRX | Amneal Pharmaceuticals Inc. | $19.57 | -2.30% | $6.8B |
| PRAX | Praxis Precision Medicines Inc. | $243.34 | -3.20% | $6.8B |
| ABVX | Abivax SA | $86.22 | -0.83% | $7.5B |
| ALKS | Alkermes plc | $39.73 | -1.32% | $6.7B |
| AXSM | Axsome Therapeutics Inc. | $156.32 | -5.83% | $8.2B |
| ARWR | Arrowhead Pharmaceuticals Inc. | $58.13 | -4.28% | $8.2B |
| KNSA | Kiniksa Pharmaceuticals International plc | $78.53 | -0.90% | $6.1B |
The full dossier has every filing, three years of financials, private raises and the people who signed them.
Open the full dossier